Name: Chi Baozhu

Gender: Female

Job title: Senior laboratory engineer

Email Address: chibaozhu@ncu.edu.cn

Education and Work Experience：

2009-present: School of Chemistry and Chemical Engineering, Nanchang University, Associate Professor

2013.09~2016.06: Nanchang University, Doctoral degree

Teaching：

Textbook

1) "Instrumental Analysis Experiment Tutorial", edited by Fang Xiuzhong and Chi Baozhu. ISBN: 978-7-03-046755-3. Science Press.

2) "College Chemistry Experiment", edited by Qu Yun and Lin Xiaoyun, with contributions from Chi Baozhu et al. ISBN: 978-7-04-040828-7. Higher Education Press.

Educational reform project

1) Teaching Research Project of Jiangxi Province Higher Education Institutions, Cultivation of College Students' Initiative Practical Ability Based on "Competition + Project" - Taking the "Analytical Chemistry Experiment" Course as an Example, Lin Xiaoyun, Chi Baozhu, Wang Min, Qu Yun.

2) Teaching Reform Research Project of Jiangxi Province Degree and Postgraduate Education, Discussion and Construction of the Connection Mode between Academic Postgraduate Training and Early Scientific Research Experience, Zhang Li, Chi Baozhu, Liang Ruping, Li Zhimei, Zheng Xiangjuan.

3) Teaching Research Project of Jiangxi Province Higher Education Institutions, Research on the Application of "Flipped Classroom" in "Analytical Chemistry" Teaching, Zhang Li, Zheng Xiangjuan, Chi Baozhu.

4) Teaching Research Project of Jiangxi Province Higher Education Institutions, Exploration of Integrating the Concept of Harmonious Efficiency into University Chemistry Theory Teaching, Li Zhimei, Zheng Xiangjuan, Chi Baozhu, Lyu Xiaolan.

Research fields:

Life analytical chemistry, chemical biosensing, preparation of photoelectric materials and their applications in the fields of biology and electrocatalysis

Research projects：

1) National Natural Science Foundation of China, 22064012, Fabrication of novel integrated molecular probe for accurate diagnosis and personalized treatment of cancer.

2) National Natural Science Foundation of China, 21907048, Development of cotrollable squaraines near-infrared fluorescence probe for single cell imaging analysis.

3) Natural Science Foundation of Jiangxi Province, 20202BAB203009, Development of controllable squaraines near-infrared fluorescent probe in medical application.

4) Natural Science Foundation of Jiangxi Province, 20171BAB213014, The applications of metal nanoclusters couple with enzyme in microRNA fluorescence sensing.

Awards and Honors：

2019-2021: Honorary title of "Excellent Undergraduate Class Tutor"

2019: The 16th "Challenge Cup" Jiangxi Province Natural Science second prize

Representative papers and patents：

Papers

1) Li Zhi-Mei, Pi Ting, Yang Ke-Fang, Xia Zi-Yi, Feng Yu-Chuan, Zheng Xiang-Juan, Deng Rui-Hong, Chi Bao-Zhu*. Label-free fluorescence strategy for methyltransferase activity assaybased on poly-thymine copper nanoclusters engineered by terminaldeoxynucleotidyl transferase. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2021, 260: 119924.

2) Yu Fu-Qing, Yan Qiu-Ming, Liang Kang-Li, Cong Zhen-Xin, Shao Qing-Qing, Wang Yi-Gang, Hong Li-Ming, Jiang Li-Xia, Ye Gui-Gui, Wang Hong-Ming, Chi Bao-Zhu*, Xia Guo-Min*. Dual-state emission and solvatofluorochromism properties of facile squaraine dyes with cis-3,5-dimethylpiperidine. Journal of Luminescence, 2021, 233: 117882.

3) Chi Bao-Zhu, Wang Chen-Lu, Wang Zhi-Qiao, Pi Ting, Zhong Xiao-Li, Deng Chao-Qun, Feng Yu-Chuan, Li Zhi-Mei*. Fluorometric determination of the activity of the biomarker terminal deoxynucleotidyl transferase via the enhancement of the fluorescence of silver nanoclusters by in-situ grown DNA tails. Microchimica Acta, 2019, 186(4): 241.

4) Chi Bao-Zhu, Liang Ru-Ping*, Yuan Yan-Hong, Zhang Li, Li Zhi-Mei, Qiu Jian-Ding*. Luminescence determination of microRNAs based on the use of terbium(III) sensitized with an enzyme-activated guanine-rich nucleotide. Microchimica Acta, 2018, 185(5): 280.

5) Chi Bao-Zhu, Liang Ru-Ping*, Qiu Wei-Bin, Yuan Yan-Hong, Qiu Jian-Ding*. Direct fluorescence detection of microRNA based on enzymatically engineered primer extension poly-thymine (EPEPT) reaction using copper nanoparticles as nano-dye. Biosensors & Bioelectronics, 2017, 87: 216-221.

6) Chi Bao-Zhu, Liang Ru-Ping, Zhang Li, Qiu Jian-Ding*. Sensitive and homogeneous microRNA detection using branched cascade enzymatic amplification. Chemical Communications, 2015, 51(52): 10543-10546.

Patents

1)Baozhu Chi, Shuyi Liu, Xiaolin Luo, Yan Xu, Hongming Wang. An Organic Dual-State Fluorescent Molecular Probe for Viscosity Detection and Its Preparation Method and Application, Invention Patent, Application, 2022-03-04, China, 202210211677.4.

2) Zhimei Li, Ting Pi,Baozhu Chi, Xiao Zhang. A Detection Method for DNA Methyltransferase Activity, Invention Patent, Application, 2018-04-24, China, 201810371607.9.

3) Ruping Liang,Baozhu Chi, Jianding Qiu. A microRNA Detection Method Based on In Situ Generation of Copper Nanoclusters by Double Polymerase Extension of Thymine, Invention Patent, Application, 2016-03-23, China, 201610167371.8.

4) Ruping Liang,Baozhu Chi, Jianding Qiu. A microRNA Detection Method Based on Guanine-Rich DNA Sensitizing Tb³⁺ Fluorescence, Invention Patent, Application, 2016-06-20, China, 201610441511.6.