Name: ZHU  Shugao

Gender: Male

Job title: Prof. Dr.

Email Address: shugaozhu@ncu.edu.cn

Education and Work Experience ：

2019.7-- present: School of Chemistry and Chemical Engineering, Nanchang University, Professor

2017.3-2019.2, University of Utah, Postdoctoral research associate, Supervisor: Prof. Danny Hung-Chieh Chou

2015.8-2017.2, Rice University, Houston, Texas, USA, Postdoctoral research associate, Supervisor: Prof. K. C. Nicolaou

2012.8-2015.6, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences，Postdoctoral research associate, Supervisor: Prof. Ang Li

2007.9-2012.6, Zhejiang University, PhD degree，Supervisor: Prof. Xian Huang

2003.9-2007.6, Wuhan University, Bachelor's degree, Supervisor: Prof. Xiang Zhou

Teaching: Organic Chemistry

Research fields: synthesis of bioactive natural products and their analogues, organic synthesis via transition metal catalysis

Research projects:

1. National Natural Science Foundation of China，2023-2026

Awards and Honors：

Representative papers and patents：

Papers:

1.Rongjing Yu, †, Ting Xia, †, Ruwei Shen, Shugao Zhu,* Diastereoselective Synthesis of Succinimide-Fused Polycycles via Intermolecular Interception of Indanone-Allene Intermediates with Maleimides, Chem. Commun., 2025, 61, 10335-10338.

2.Ting Xia, Rongjing Yu, Jingjing Chen, Zebang Meng, Ruwei Shen, Shugao Zhu,* Synthesis of Fused Polycyclic Indole-Indenone Scaffolds via Pd-Catalyzed Sequential Cycloaddition Reactions, Org. Lett., 2025, 27, 24, 6415–6421.

3.Shugao Zhu,* Yuxuan Fang, Yu Xin, Rui Zhang, Shihan Liu, * Yu Lan, Ruwei Shen，Palladium-Catalyzed Tandem Reactions via Allene Intermediates for the Rapid Synthesis of Fused Indenone-Indole Scaffold, Org. Lett., 2025, 27, 4, 967-972.

4.Shugao Zhu,* Rui Zhang, Ting Xia, Rongjing Yu, Shihan Liu,*, Yu Lan, Ruwei Shen, Divergent Access to Polycyclic Fluorenofuran Systems via Palladium-Catalyzed Cascade Furan-Participated Diels-Alder Cycloaddition Reactions, Org. Lett., 2024，26，10746-10751.

5.Shugao Zhu,* Hong Wang, Shihan Liu,* Rongjing Yu, Yufeng Ma, Rui Zhang, Yuxuan Fang, Yu Lan, and Ruwei Shen; Access to Indenofluorene Skeletons via Pd-Catalyzed Sequential Reaction Involving Cyclization of Indenone-Allenyne intermediates, Org. Chem. Front., 2024, Advance Article.

6.Shugao Zhu,* Wenliang Huang, Shihan Liu, Rongjing Yu, Yufeng Ma, Hong Wang, Rui Zhang, Bin Liu, Yu Lan* and Ruwei Shen; Synthesis of Benzooxepane-Fused Cyclobutene Derivatives via Pd-Catalyzed Cascade Reactions of Haloarenes and Diynylic Ethers, Chem. Commun., 2024, 60, 5707-5710.

7.Shugao Zhu^*; Dan Wang; Shihan Liu; Yufeng Ma; Hong Wang; Yu Lan^*; Ruopeng Bai; Ruwei Shen^*; Palladium-Catalyzed Cross-Coupling, Divergent Allene Generation, and Cycloadditions toward Cyclobuta[b]naphthalen-3(1H)-ones and 11H-Benzo[b]fluoren-11-ones, ACS Catalysis, 2023, 13(13): 8402–8412.

8.Wenliang Huang; Hong Wang; Bin Liu^*; Ruwei Shen^*; Shugao Zhu^*; Synthesis of 1,1,4,5-Tetrasubstituted Phthalans via Pd-Catalyzed Three-Component Reactions of Haloarenes, Alkynes, and Protic Nucleophiles, Oganic Letters, 2022, 24(47): 8651−8656.

9.Li, Xiaojie; Xiao, Tianyu; He, Guangke; Zhu, Shugao; Zhu, Dunru; Shen, Ruwei^*; Pyrrolidine-Catalyzed Annulations of Quinone Monoacetals with Naphthols: Synthesis of 2-Oxabicyclo[3.3.1]nonane Skeletons, Transformations and Reaction Mechanism, Advanced Synthesis & Catalysis, 2022, 364(3): 622-636.

10.K. C. Nicolaou^*; Pengxi Chen; Shugao Zhu; Quan Cai; Rohan D. Erande; Ruofan Li; Hongbao Sun; Kiran Kumar Pulukuri; Stephan Rigol; Monette Aujay; Joseph Sandoval; Julia Gavrilyuk; Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues, Journal of the American Chemical Society, 2017, 139(43): 15467-15478.

11.Yong Li^#; Shugao Zhu^#; Jian Li; Ang Li^*; Asymmetric Total Syntheses of Aspidodasycarpine, Lonicerine, and the Proposed Structure of Lanciferine, Journal of the American Chemical Society, 2016, 138(12): 3982-3985.

12.Nicolaou K C^*; Cai Quan; Sun Hongbao; Qin Bo; Zhu Shugao; Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7"-epi-C and Full Structural Assignment of Trioxacarcin C, Journal of the American Chemical Society, 2016, 138(9): 3118-3124.

13.Shen Ruwei^*; Yang Jianjun; Zhu Shugao; Chen Chao; Wu Luling; Gold(I)-Catalyzed Decarboxylation of Propargyl Carbonates: Reactivity Reversal of the Gold Catalyst from pi-Lewis Acidity to sigma-Lewis Acidity, Advanced Synthesis & Catalysis, 2015, 357(6): 1259-1269.

14.Zhu Shugao; Wu Luling^*; Huang Xian; Gold-Catalyzed Cyclization of 3-(2 '-Azidoaryl)-1-arylpropargyl Carbonates or 3-Aryl-1-(2 '-azidoaryl)propargyl Carbonates to Produce Quinolines, Journal of Organic Chemistry, 2013, 78(18): 9120-9126.

15.Jianfeng Xu; Shugao Zhu; Luling Wu^*; Xian Huang; Chemoselective synthesis of highly substituted 1,2-allenyl ketones,   furans, and 2-alkynyl ketones from reaction of lithium selenolates with   1-(1-alkynyl) cyclopropyl ketones and electrophiles, Organic and Biomolecular Chemistry, 2012, 10(18): 3705-3714.

16.Zhu Shugao; Wu Luling^*; Huang Xian; Palladium-catalyzed sequential reaction via Sonogashira coupling,   isomerization, Claisen rearrangement and [4 2] cycloaddition sequence   for the rapid synthesis of tricyclo[3.2.1.0(2,7)]oct-3-ene derivatives, RSC Advances, 2012, 2(1): 132-134.

17.Zhu Shugao; Wu Luling^*; Huang Xian; Palladium(0)-catalyzed cyclization of 1,6-diyn-3-yl carbonates with a   nucleophilic functionality: efficient synthesis of polycyclic   benzo[b]fluorene derivatives via allene intermediates, Organic and Biomolecular Chemistry, 2012, 10(18): 3696-3704.

18.Shugao Zhu; Jian Cao; Luling Wu^*; Xian Huang; Synthesis of Polycyclic Isoindoline Derivatives via Tandem Pd-Catalyzed   Coupling, Propargyl-Allenyl Isomerization, [4 2] Cycloaddition and   Aromatization Reaction, Journal of Organic Chemistry, 2012, 77(22): 10409-10415.

19.Ruwei Shen; Shugao Zhu; Xian Huang^*; Unexpected Pd-Catalyzed Coupling, Propargyl-Allenyl Isomerization and   Alder-Ene Reaction: Facile Synthesis of Some Not Readily Available   2,3-Dihydrofuran Derivatives, Journal of Organic Chemistry, 2009, 74(11): 4118-4123.

20.Xian Huang^*; Shugao Zhu; Ruwei Shen; Palladium-Catalyzed Sequential Reactions via Allene Intermediates for   the Rapid Synthesis of Fused Polycyclic Pyrrole Derivatives, Advanced Synthesis & Catalysis, 2009, 351(18): 3118-3122.

21.Weng Xiaocheng; Ren Lige; Weng Liwei; Huang Jing; Zhu Shugao; Zhou Xiang^*; Weng Linhong; Synthesis and biological studies of inducible DNA cross-linking agents, Angewandte Chemie International Edition, 2007, 46(42): 8020-8023.

Patents:

1. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogs Thereof.

K. C. Nicolaou*, P. Chen, S. Zhu, Q Cai. PCT Int. Appl. (2019), WO 2019036537 A1 20190221.